Background and aims: Risk of progression in Barrett's esophagus (BE) with low-grade dysplasia (LGD) and high-grade dysplasia (HGD) has been established. However, the natural history of BE with indefinite dysplasia (BE-IND) remains unclear. We performed a systematic review and meta-analysis to estimate the pooled risk of progression to HGD …
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In this work, we report 11 novel HGD mutations identified during analysis of 36 AKU patients and 41 family members from 27 families originating from 9 different countries, …
The presence of high-grade dysplasia (HGD) or villous component (VC) defines an advanced adenoma (AA) in patients with 1 or 2 adenomas <1 cm in size. Current consensus guidelines recommend that patients with AA undergo more intense postpolypectomy surveillance. In these clinical situations, the interobserver reliability in …
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Background Esophagectomy has been the standard treatment for Barrett's esophagus (BE) with high-grade dysplasia (HGD) and intramucosal cancer (IMC). Recently, endoscopic mucosal resection (EMR) and radiofrequency ablation (RFA) have become the preferred treatment for these patients in some centers. We report a single institution …
We compared both serum levels and urinary excretion of HGA in patients who are homozygous for the G161R variant (1% residual HGD activity, Group A) to those …
Alkaptonuria (AKU) is a rare metabolic disorder caused by a deficient enzyme in the tyrosine degradation pathway, homogentisate 1,2-dioxygenase (HGD).
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Biopsies revealed high-grade dysplasia (HGD) and the patient is referred to a tertiary care referral center for endoscopic eradication therapy (EET). His symptoms …
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The management of BE with high-grade dysplasia (HGD) is controversial. Multiple guidelines exist with respect to the management of HGD. 3, 4 Traditionally, the main options were endoscopic surveillance or eradication of HGD through surgical resection of the esophagus. There has been some controversy about the risk of progression of HGD to ...
Alkaptonuria (AKU) is an autosomal recessive disorder caused by a deficiency of homogentisate 1,2 dioxygenase (HGD) and characterized by homogentisic aciduria, …
HGD attorneys Steve Heninger and Gayle Douglas served on the plaintiff's legal team. In May 2012, a federal jury in Montgomery, Alabama handed down a $64 million verdict against VictoryLand greyhound racing park and its owner Milton McGregor in a civil lawsuit that claimed he conspired with Macon County's sheriff to give the dog track a ...
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Alkaptonuria (AKU) is an autosomal recessive disorder caused by a deficiency of homogentisate 1,2 dioxygenase (HGD) and characterized by homogentisic aciduria, ochronosis, and ochronotic arthritis. The defect is caused by mutations in the HGD gene, which maps to the human chromosome 3q21–q23. AKU shows a very low prevalence …
Adequate time should be spent inspecting the Barrett's epithelium; a study published in 2012 showed a significant correlation between the Barrett's inspection time and the yield of HGD or EAC, with significantly higher detection with an inspection time of ≥1 minute per centimeter of BE . Nodular lesions or visible abnormalities within ...
The HGD-mutation database includes all HGD variants and AKU patients reported so far. Database also incorporates the data in the original AKU mutation database located in Madrid (updated last in 2001), in agreement with Prof. Santiago Rodriguez de Cordoba. Zatkova et al. (2012): Identification of eleven novel homogentisate 1,2 dioxygenase …
Alkaptonuria (AKU) is a rare autosomal recessive disorder with incidence ranging from 1:100,000 to 1:250,000. The disorder is caused by a deficiency of the enzyme homogentisate 1,2-dioxygenase (HGD), which results from defects in the HGD gene. This enzyme converts homogentisic acid to maleylacetoacetate and has a major role in the …
Alkaptonuria (AKU) [OMIM 203500] is caused by deficiency of homogentisate-1,2-dioxygenase (HGD, EC 1.13.11.5). 1 Darkening of the urine upon …
From our patient database, we identified 26 patients with an ampullary mass seen on EGD from 2012-2016. Of these patients, 15 were diagnosed with either tubular adenoma or tubulovillous adenoma on EGD biopsy and underwent a transduodenal resection with curative intent. The majority of the lesions were ampullary. ... (HGD) or …
HGD and EAC incidences were 49.19 and 16.48 per 1,000 person-years of follow-up, respectively; 10-year cumulative HGD and EAC incidences post-BE diagnosis were 0.40 and 0.17, respectively.
The rate of local adenoma recurrence in our study was 23%, which is within the reported range of 14%-24% of the published literature for HGD/IMCA. 1, 14, 5 Studies from Asia have demonstrated a 0.8%-1.9% rate of malignant recurrence for CRAs with HGD/IMCA, especially after p-ER. 1, 15, 16 In the present study, 2 patients (1.6%) who …
Background & aims: Recent studies have claimed long neoplasia-free survival rates with endoscopic mucosal resection of high-grade dysplasia (HGD) in Barrett's esophagus (BE). However, reports have contended that approximately 40% of patients who have esophagectomy for HGD have occult invasive cancer.
Introduction. Alkaptonuria (AKU) [OMIM 203500] is caused by deficiency of homogentisate-1,2-dioxygenase (HGD, EC 1.13.11.5). 1 Darkening of the urine upon standing is usually the first sign of AKU, characteristic of homogentisic acid excretion. Homogentisic acid accumulated in the body forms a melanin-like polymer that is …
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A retrospective review was conducted from September 1, 2004, to August 31, 2009, identifying 246 patients (SCC 132; HGD 114) presenting to the BCCA. Surgery was done under FV guidance in 149 patients while 97 were treated conventionally. Outcome measures included pathology-proven local recurrence, regional failure, and death. Results
HGD. CUSIP. 08661P305. Inception Date. June 25, 2007. Net Assets The value of all assets, less the value of all liabilities, at a particular point in time. (Includes all classes of this ETF) $22,502,546 As at June 20, 2024. Consolidated Prior Day Volume The ETF's aggregate volume traded on all Canadian exchanges.
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Background and study aims: In patients with Barrett's esophagus (BE), targeted endoscopic mucosal resection (EMR) of visible lesions of high grade dysplasia (HGD) or intramucosal adenocarcinoma (IMC) is effective, but carries the risk of leaving in place synchronous lesions and Barrett's epithelium with the potential for recurrent disease. . We evaluated …
The presence of high-grade dysplasia (HGD) or villous component (VC) defines an advanced adenoma (AA) in patients with 1 or 2 adenomas <1 cm in size. Current consensus guidelines recommend that patients with AA undergo more intense postpolypectomy surveillance. In these clinical situations, the interobserver reliability in …
HGD in the setting of BE has been identified as a key risk factor in the progression to esophageal adenocarcinoma (EA). Patients with HGD are at a higher risk for progressing to EA than are patients with BE with no or low-grade dysplasia (LGD). This has given rise to performing prophylactic esophagectomy for the treatment of HGD to …
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Alkaptonuria (AKU) [OMIM 203500] was the first genetic disease identified [], which is characterized by deficiency of homogentisate 1,2-dioxygenase (HGD) (EC 1.13.11.5), an enzyme involved in the ...
Alkaptonuria is caused by a deficiency of the enzyme homogentisate 1,2-dioxygenase (HGD), the third enzyme of the tyrosine degradation pathway . Biallelic …
Abstract. High-grade dysplasia (HGD) in Barrett's esophagus (BE) is the critical step before invasive esophageal adenocarcinoma. Although its natural history remains unclear, an aggressive therapeutic approach is usually indicated. Esophagectomy represents the only treatment able to reliably eradicate the neoplastic epithelium.
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